Monday, April 29, 2013

Google's virtual assistant invades Siri's turf

(AP) ? Google is trying to upstage Siri, the sometimes droll assistant that answers questions and helps people manage their lives on Apple's iPhone and iPad.

The duel begins Monday with the release of a free iPhone and iPad app that features Google Now, a technology that performs many of the same functions as Siri.

It's the first time that Google Now has been available on smartphones and tablet computers that aren't running on the latest version of Google's Android software. The technology, which debuted nine months ago, is being included in an upgrade to Google's search application for iOS, the Apple Inc. software that powers the iPhone, iPad and iPod Touch. It's up to each user to decide whether to activate Google Now within the redesigned search app.

Google Now's invasion of Siri's turf marks Google Inc.'s latest attempt to lure iPhone and iPad users away from a service that Apple built into its own devices.

Google quickly won over millions of iPhone users in December when it released a mapping application to replace the navigation system that Apple dumped when it redesigned iOS last fall. Apple's maps application proved to be far inferior to Google's ousted service. The app's bugs and glitches made Apple the butt of jokes and fueled demand for Google to develop a new option.

Apple has been losing to Google on other fronts in a rapidly growing mobile computing market, an arena that was revolutionized with the iPhone's release in 2007. Smartphones and tablet computers running Google's free Android software have been steadily expanding their market share in recent years, partly because they tend to be less expensive than the iPhone and iPad. At the end of 2012, Android devices held about 69 percent of the smartphone market while iOS held about 19 percent, according to the research firm IDC.

Android's success has been particularly galling for Apple because its late CEO Steve Jobs believed Google stole many of its ideas for the software from the iPhone. That led to a series of court battles over alleged patent infringement, including a high-profile trial last year that culminated in Apple winning hundreds of millions in damages from Samsung Electronics, the top seller of Android phones. That dispute is still embroiled in appeals.

The rise of Android also is squeezing Apple's profit margins, and has contributed to a 40 percent drop in the company's stock price since it peaked at $705.07 last September around the time that the iPhone 5 came out.

Android's popularity is good news for Google because the company's services are built into most versions of the operating system. That brings more traffic to Google services, creating more opportunities for the company to sell ads ? the main source of Google's revenue.

Siri, billed by Apple as an "intelligent feature." Since the technology's release in October 2011, Apple has made it a centerpiece of some marketing campaigns that depict Siri and its automated female voice as an endearing and occasionally even pithy companion.

When asked for an opinion about Google Now, Siri responded: "If it's all the same to you, I'd rather Google later."

Google believes its Siri counterpart is smarter because Google Now is designed to learn about a user's preferences and then provide helpful information before it's even asked to do so. The technology draws upon information that Google gleans from search requests other interactions with the company's other services. Knowing a person's location also helps Google Now serve up helpful information without being asked.

"This concept of predicting your needs and showing you them at the right time is unique to Google Now," said Baris Gultekin, Google Now's director of product management. "We want computers to do the hard work so our users can focus on what matters to them so they can get on with their lives."

If the technology is working right, Google Now is supposed to do things like automatically tell people what the local weather is like when they awaken to help decide what to wear and provide a report on traffic conditions for the commute to work. During the day, Google Now might provide an update on the score of a user's favorite sports team or a stock quote of a company in a user's investment portfolio. On a Friday evening, Google Now might offer suggestions for movies to see or other weekend events tailored to a user's interests. For international travelers, Google Now might provide currency conversion rates, language translations of common phrases and the time back home.

Most of this automatic information is provided in summaries that Google calls "cards." Like Siri, Google Now also is equipped with voice technology that allows it to respond to questions and interact with users, though it hasn't shown the wit that amuses some of Siri's users.

The Google Now app for iOS isn't as comprehensive as the Android app, which only works on devices running on the latest version of Android ? known as "Jelly Bean." Some of the Android features missing from Google Now's iOS app include cards for showing airline boarding passes and movie tickets bought though online vendor Fandango. Both of those options are available on the iOS through Apple's built-in Passbook feature that's designed to be a digital wallet.

Google Now's expansion on to the iOS underscores Google's ambitions for the service. The company, which is based in Mountain View, Calif., views it as a pivotal tool in its effort to peer deeper into its users' brains. In doing so, Google believes it will be able to provide more useful services and also show more relevant ads. For Google Now to become more intuitive, it needs to widen its availability.

"The more you use Google Now, we will have a better chance of understanding what your needs are and providing you with the right information," Gultekin said. "It's a virtuous cycle."

Gultekin declined to discuss whether there are plans to make Google Now apps for mobile devices running on Microsoft's Windows system. He also refused to comment on speculation circulating in technology blogs that a Web version of Google Now will be offered as a replacement for iGoogle, a tool that allows people to encircle the Google search engine with a variety of services suited to their tastes. IGoogle is scheduled to close in November.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2013-04-29-Google-Apple-Dueling%20Assistants/id-636531294cf7433eb0077c22e032a924

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Shazam Brings On Former Yahoo Exec Rich Riley To Position For Growth And IPO

rileyIn March last year Yahoo?s SVP of the Europe, the Middle East and Africa region abruptly quit his role in the rejuvenation of Yahoo, supposedly to be closer to family in Sunnyvale. However, after an orderly departure he's now joined Shazam, the mobile music discovery app as CEO. Longtime CEO Andrew Fisher (since 2005) will become executive chairman. The London-based Shazam says it now has 300 million users in 200 countries, with 90 million of them in the U.S. and calls itself a "media engagement company."

Source: http://feedproxy.google.com/~r/Techcrunch/~3/AeD0_y_jB8k/

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MallWeGo Is A Social Shopping And Gaming Platform To Make Buying Stuff More Fun

mallwegoMallWeGo is launching at the Disrupt NY 2013 Startup Alley today with a social, gaming shopping experience for web and mobile. The company has built a virtual world for socialising with friends in avatar form, which looks like a simplified Second Life or The Sims, but the kicker is it's built for ecommerce, with a virtual mall where people can buy real-world products.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/qEzvve53JV0/

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Samsung Galaxy Mega hits FCC (again), this time with LTE

Samsung Galaxy Mega hits FCC again, this time with LTE

Better start working on those powerball exercises. At least if Samsung's Galaxy Mega was the thing you thought your life was missing, as it's just landed at the FCC. Yeah, we know this isn't the first time, but on second time around it's the LTE-sporting GT-i9205 model. The usual lab tests show little that we didn't know already -- unless you didn't know it had LTE Band 5, dual band WiFi, NFC or GSM 850 / 1900. As the 5.8-inch isn't 4G-enabled, this means we're looking at the bigger 6.3-inch version, but still no word on if, when or how a version might land on US shores. Still no harm in limbering up though, is there?

Update: Upon further inspection, this variant only uses LTE band 5 (850mhz), which no us carrier currently uses. It's very unlikely this I9205 will hit the US.

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Source: FCC

Source: http://www.engadget.com/2013/04/28/samsung-galaxy-mega-lte-fcc/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Microsoft's Crazy IllumiRoom: More Details About a Real-Life Holodeck

Not too long ago, Microsoft introduced its grand, pie-in-the-sky plans to maybe, someday turn your entire wall into an extension of your TV screen. Now, Microsoft Research has dropped some new details about how it all would work, and it's shaping up to be pretty awesome.

The IllumiRoom would take the physical form of a small, wide-angle projection box that would sit on your coffee table, facing the TV. From there, it would feed off all kinds of information?from tapping right into a game's source code, to reading raw controller input?to apply all manner of effects.

On the developer side, IllumiRoom would offer a wide variety of options from blowing out the whole screen to the walls, letting just explosions and gunshots bleed onto the nearby walls, having objects seem to fall off the screen and onto the floor, adding abstract reality-warping effects, or any combination of the above.

While we've got a little more detail here about how this tech would be applied, it's still just a Microsoft Research project, and the information we're getting is pretty high-level and conceptual. Even so, it's a neat take on goggle-less virtual reality that could prove to be seriously awesome in the right hands. Here's to hoping we see some prototypes in actually reality soon. [Microsoft IllumiRoom via The Verge]

Source: http://gizmodo.com/microsofts-crazy-illumiroom-more-details-about-a-real-484384917

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The Party Of Morning Joe (Atlantic Politics Channel)

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Obama jokes about radical 2nd term changes

President Barack Obama speaks at the White House Correspondents' Association Dinner at the Washington Hilton Hotel, Saturday, April 27, 2013, in Washington. (AP Photo/Carolyn Kaster)

President Barack Obama speaks at the White House Correspondents' Association Dinner at the Washington Hilton Hotel, Saturday, April 27, 2013, in Washington. (AP Photo/Carolyn Kaster)

Michael Douglas poses for a photo during the White House Correspondents' Association Dinner at the Washington Hilton Hotel, Saturday, April 27, 2013, in Washington. (AP Photo/Carolyn Kaster)

President Barack Obama talks with Michael Clemente, Executive Vice President of Fox News, the White House Correspondents' Association Dinner at the Washington Hilton Hotel, Saturday, April 27, 2013, in Washington. (AP Photo/Carolyn Kaster)

President Barack Obama looks to the podium during the White House Correspondents' Association Dinner at the Washington Hilton Hotel, Saturday, April 27, 2013, in Washington. (AP Photo/Carolyn Kaster)

First lady Michelle Obama, right, and late-night television host Conan O'Brien attend the White House Correspondents' Association Dinner at the Washington Hilton Hotel, Saturday, April 27, 2013, in Washington. (AP Photo/Carolyn Kaster)

(AP) ? President Barack Obama joked Saturday about his plans for a radical second-term evolution from a "strapping young Muslim Socialist" to retiree golfer, all with a new hairstyle like first lady Michelle's.

Obama used this year's annual White House Correspondents' Association dinner to poke fun at himself and some of his political adversaries, asking if it was still possible to be brought down a peg after 4? years as commander-in-chief.

Entering to the rap track "All I Do Is Win" by DJ Khaled, Obama joked about how re-election would allow him to unleash a radical agenda. But then he showed a picture of himself golfing on a mock magazine cover of "Senior Leisure."

"I'm not the strapping young Muslim Socialist that I used to be," the president remarked, and then recounted his recent 2-for-22 basketball shooting performance at the White House Easter Egg hunt.

But Obama's most dramatic shift for the next four years appeared to be aesthetic. He presented a montage of shots featuring him with bangs similar to those sometimes sported by his wife.

Obama closed by noting the nation's recent tragedies in Massachusetts and Texas, praising Americans of all stripes from first responders to local journalists for serving the public good.

Saturday night's banquet not far from the White House attracted the usual assortment of stars from Hollywood and beyond. Actors Kevin Spacey, Julia Louis-Dreyfus and Claire Danes, who play government characters on series, were among the attendees, as was Korean entertainer Psy. Several Cabinet members, governors and members of Congress were present.

And despite coming at a somber time, nearly two weeks after the deadly Boston Marathon bombing and 10 days after a devastating fertilizer plant explosion in West, Texas, the president and political allies and rivals alike took the opportunity to enjoy some humor. Late-night talk-show host Conan O'Brien headlined the event.

Some of Obama's jokes came at his Republican rivals' expense. He asked that the GOP's minority outreach begin with him as a "trial run" and said he'd take his recent charm offensive with Republicans on the road, including to a book-burning event with Rep. Michele Bachmann.

Casino magnate Sheldon Adelson would have had better success getting Obama out of office if he simply offered the president $100 million to drop out of last year's race, Obama quipped.

And on the 2016 election, the president noted in self-referential irony that potential Republican candidate Sen. Marco Rubio wasn't qualified because he hasn't even served a full term in the Senate. Obama served less than four years of his six-year Senate term before he was elected president in 2008.

The gala also was an opportunity for six journalists, including Associated Press White House Correspondent Julie Pace, to be honored for their coverage of the presidency and national issues.

The New Yorker's Ryan Lizza won the Aldo Beckman Award, which recognizes excellence in the coverage of the presidency.

Pace won the Merriman Smith Award for a print journalist for coverage on deadline.

ABC's Terry Moran was the winner of the broadcast Merriman Smith Award for deadline reporting.

Reporters Jim Morris, Chris Hamby and Ronnie Greene of the Center for Public Integrity won the Edgar A. Poe Award for coverage of issues of national significance.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-04-28-Obama-Correspondents/id-1a7e0adf2fe942a09d0e7c06006139d2

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Saturday, April 27, 2013

Obama: Syrian government use of chemical weapons a "game changer"

* Lewandowski scored four goals against Real Madrid * Poland international refuses contract extension (adds details, background) BERLIN, April 26 (Reuters) - Bayern Munich and Borussia Dortmund striker Robert Lewandowski have not signed a deal, the newly-crowned champions said on Friday, shooting down widespread speculation of another imminent surprise transfer. "Bayern, as opposed to some reports, has no contract with Robert Lewandowski," the Bavarian Champions League semi-finalists said in a brief statement. ...

Source: http://news.yahoo.com/obama-syrian-government-chemical-weapons-game-changer-183303953.html

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Rachel Maddow on the Mainstreaming of Crackpot Conspiracy Theories by the Right Wing (Little green footballs)

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Fotopedia Reporter for iPad lets photographers publish their own photo stories

Fotopedia Reporter is a gorgeous app that lets you create your own photo stories and publish them to the popular social magazine. Whether it's a gallery from your last vacation, a tour of your garden, a review of your favorite restaurant, there's a place for your editorial creativity on Fotopedia.

Creating a photo story is easy: start with a cover photo, choose a title and description, add a location, pull text from Wikipedia or add your own, and share for all to see!

In addition to sharing your own stories, you can also browse stories posted by other people. Fotopedia has a featured page of great content as well as the most popular and new stories organized by category.

Fotopedia is very social at lets you rate stories up to 5 stars as well as leave comments. You can also follow users and see all their work viewed as a list or thumbnails.

The good

  • Stunning design
  • Easy to create a photo story
  • Find amazing work by other users
  • Organize by featured or category (new or popular)
  • Leaving ratings and comments
  • Follow users and view profiles
  • Share to Facebook and Twitter

The bad

  • No complaints

The bottom line

Fotopedia Reporter is incredibly well designed and is a great way for photographers to showcase their work. I am in awe by some of the photos I've come across and it makes me want to pick a theme and take a stab at photojournalism.

    


Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/CoGB8ldagU4/story01.htm

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Friday, April 26, 2013

Possible 9/11 plane landing gear part found in NYC

NEW YORK (AP) ? A rusted 5-foot-tall piece of landing gear believed to be from one of the hijacked planes destroyed in the Sept. 11 attacks has been discovered near the World Trade Center wedged between a luxury apartment building and a mosque site that once prompted virulent national debate about Islam and free speech.

The twisted metal part, jammed in an 18-inch-wide sliver of open space between the buildings, has cables and levers on it and is about 17 inches wide and 4 feet long, New York Police Department Commissioner Raymond Kelly said Friday.

"It's a manifestation of a horrific terrorist act a block and a half away from where we stand," he said. "So, sure, it brings back terrible memories to anyone who was here or who was involved in that event."

Kelly edged down the narrow passageway to look at the object Friday evening, noting there is also a piece of rope intertwined with the part in what looks like a broken pulley that may have come down from the roof of the site of the planned Islamic community center, at 51 Park Place.

The piece of equipment was discovered Wednesday by surveyors inspecting the lower Manhattan site of a planned Islamic community center on behalf of the building's owner, police said.

An inspector was on the roof and noticed the debris and then called 911. Police secured the scene, documenting it with photos.

It includes a clearly visible Boeing Co. identification number, New York Police Department spokesman Paul Browne said.

"The odds of this being wedged between there is amazing," Browne said, adding it was not surprising that it went undiscovered for more than a decade given the location. "It had to have fallen just the right way to make it into that space."

Other World Trade Center wreckage had been discovered at the buildings and around the area in years past.

Police detectives and National Transportation Safety Board investigators will determine whether the equipment is from the American Airlines plane or the United Airlines plane that slammed into the twin towers on Sept. 11, 2001, destroying the towers and killing nearly 3,000 people.

When plans for the Islamic center, about three blocks from ground zero, were made public in 2010, opponents said they didn't want a mosque so close to where Islamic extremists attacked. They argued the site was "sacred" because landing gear from one of the hijacked Boeing 767 jets had punctured the roof of the building on Sept. 11.

During street protests, they clashed with supporters of the center, who said it would promote harmony between Muslims and followers of other faiths.

The building includes a Muslim prayer space that has been open for three years. After protests died down, the center hosted its first exhibit last year. The space remains under renovation.

Donna Marsh O'Connor, who lost her daughter Vanessa Lang Langer in the attacks and is a member of September 11th Families for a Peaceful Tomorrow, called the landing gear discovery "bizarre."

O'Connor is a supporter of the Islamic center and said the fact that the plane fragment was found there "makes me think that this was the right place for a center that was going to heal the divide."

In a statement, Sharif El-Gamal, the president of Soho Properties, which owns 51 Park Place, said workers called the city and the police as soon as they discovered the landing gear. He said the company is cooperating with the city and the police to make sure the piece of equipment "is removed with care as quickly and effectively as possible."

The medical examiner's office will complete a health and safety evaluation to determine whether to sift the soil around the buildings for possible human remains, police said.

Patricia Riley, whose sister Lorraine Riley was killed in the Sept. 11 attacks, called the landing gear discovery "very strange."

"Twelve years later we are still finding remnants of the attack on our country," she said. "... For years to come we'll continue to find things that we didn't see before. Hopefully, they'll serve as a reminder that we have to stay vigilant."

Outside the Islamic center building, known as Park51, a police officer stood next to the door on Friday and a police barricade was set up to contain the many journalists who had gathered to try to see the piece of the plane.

The landing gear could not be seen from the sidewalk so commuters rushed by and looked quizzically at the gathering.

Among the bystanders was one immersed in the legacy of the attacks: Van Vanable, heading home from his job as an ironworker building the new 1 World Trade Center.

"Amazing," he said of the find. "There's still pieces to the puzzle."

The Park51 space, a former Burlington Coat factory, is a five-story, mildly run-down building. Renovations are expected to take years and would add an auditorium, a pool, a restaurant and culinary school, a child care facility and artist studios.

The piece of plane is wedged in an alley space between that building and 50 Murray St., a luxury loft rental building.

___

Associated Press writers Tom Hays, Jennifer Peltz, Colleen Long and Karen Matthews in New York and David B. Caruso in Boston contributed to this report.

Source: http://news.yahoo.com/possible-9-11-plane-landing-gear-part-found-220156560.html

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Marathon bombing prompts backpack bans

Left unattended, no accessory looks as menacing these days as a backpack.

At the airport. On the subway. At a sports event.

And, as a result of the two backpack-encased bombs that exploded near the finish line at the Boston Marathon, sports teams and leagues around the world are rethinking what kind of bags, satchels, purses and, yes, black nylon backpacks should be allowed inside stadiums and arenas.

The packs will even be the focal point of a conference this summer of stadium-security personnel in Orlando .

"After what happened ... I wouldn't be surprised if the number of people eliminating backpacks would increase," said Lou Marciani, director of the National Center for Spectator Sports Safety and Security, founded in 2006 and based at the University of Southern Mississippi in Hattiesburg.

Next Saturday, more than 165,000 people are expected at Churchill Downs for the Kentucky Derby. Backpacks, duffel bags and large purses have been banned from the track since 2002 ? part of the clamp-down that followed the Sept. 11 attacks. Still, Derby officials have told fans their bags will undergo increased security checks for this year's race.

No matter where the world ends up on the bag-check spectrum, some fans may never again regard the pack slung across their body quite the same way.

"I never really thought about backpacks until last week, and now you notice backpacks all over the place," said Ryan Hershberger of Hartwell, Ga., as he headed into a Colorado Rockies game carrying a black backpack. "It makes you think."

Down the street, at the Denver Nuggets game, a handful of fans shared the same sentiment.

"I've been thinking about it all day," Joel Cross said on the concourse at the Pepsi Center in Denver. He and his wife traveled from Harrisburg, Neb., to attend Tuesday night's Nuggets playoff game. "We're from a community where our whole county only has 600 people in it. Nobody is going to bomb us because there's no one there. But we're coming to a populated area."

The NFL beefed up security for thousands of fans attending its annual draft, which runs through Saturday, with metal detectors, pat-downs and about 20 percent more personnel in place than previous years. Backpacks are banned. The league said it would consider what, if any, changes might be made for the 2013 season, which ends with the Super Bowl in New York next February.

Major League Baseball's security officials met Thursday but Commissioner Bud Selig said no changes are expected in the rules on bags fans can bring to ballparks, generally limited to 16x16x8 inches. The meeting was scheduled before the Boston explosions that killed three and injured more than 260/

"I wouldn't say that Boston has changed anything," Selig said. "Each club makes its own decision."

At Yankee Stadium, for example, briefcases, coolers and other hard-sided bags or containers are not permitted. At Kansas City's Kauffman Stadium, wrapped presents are banned along with cameras with lenses of 12 or more inches. The Baltimore Orioles ban bags with wheels at Camden Yards.

Boston and San Francisco were among the teams opting to use metal-detecting wands on fans and their possessions this week.

"We've added people, and people are getting in faster now, so we're going to stick with the plan," Giants president and CEO Larry Baer said.

Though the marathon bombings caught the attention of the world, not every event or championship, especially overseas, is beefing up or changing security measures.

For instance, officials at Manchester United, the FA Cup final and the European Champions League say their policies, which either ban large bags or strongly discourage them, are under constant review but not set to change.

"We did, of course, contact the police in the aftermath of the Boston bombings, as part of our commitment to the security of fans and visitors to the stadium," Manchester United said in a statement.

At Wimbledon, where tennis action starts in June, no changes are planned.

"It was a terrible event, but we have no reason to believe it's something that has a direct impact on Wimbledon," All-England Club chief executive Richard Lewis said, referring to the Boston explosions.

At the Summer Olympics in London, soft-sided bags were required to fit under seats and couldn't hold more than 25 liters (6 gallons).

Sebastian Coe, who led London's organizing committee, says a ban on backpacks at sports events would not be justified.

"We have to make some pretty tough decisions in the way we want to live our lives," he said. "It's very easy to draw all sorts of conclusions (from the Boston bombings). Do we want to live in a world where people can't wear backpacks to sporting events? I'm not sure we do."

Organizers in Brazil aren't making any radical changes to their backpack policy for the upcoming Confederations Cup or next year's World Cup. So far, the extensive list of prohibited items includes "unwieldy" bags ? no more than 10x10x10 inches and too big to fit under a seat.

Officials in Russia, which hosts the 2018 World Cup, said that whenever a sports-related tragedy occurs, they review what happened "to ensure that our own regulations and procedures are sufficiently covering such potential tragedies or risks."

In Sochi, Russia, site of February's Winter Olympics, security for test events was so stringent that the president of the international skiing federation, Gian Franco Kasper, cracked, "The only moment they didn't inspect our athletes was during the race."

International Olympic Committee member Dick Pound of Canada said one strategy might be to push back security boundaries.

"I remember in Vancouver and other places, the tension between the organizers and the events and the security folks was over the size of the perimeter," Pound said. "If you can move the perimeter back 50 or 100 meters, a backpack bomb is going to have less lethal effect."

In the U.S., NBA spokesman Tim Frank wouldn't comment on specific security practices, beyond saying: "We regularly practice a wide range of state of the art security measures in all of our arenas." The Nuggets have long used wands and searched bags. But Cross' wife, Shelly, said she noticed a more extensive security presence at Tuesday's game than the last time they made the trip to Denver.

"We were here not too long ago and we don't remember this," she said.

At least one backpack developer said she was unaware of any pending changes to basic designs. She also thought the bombings were unlikely to create a need for see-thru or clear backpacks.

"I don't think people want to share their belongings with everyone. Everyone wants their privacy," said Annelies Mertens, a member of the Samsonite development team in Belgium. "I don't think this will have an influence on the way backpacks are made. I don't see that happening."

While the Boston Marathon presented its own set of difficult challenges ? securing a 26-mile course dotted with trash cans and spectators on almost every block ? one expert says there's no such thing as perfect security guidelines, regardless of venue.

"A no-backpack policy is fine if it applies to everyone," said Derek Catsam, an associate professor at University of Texas of the Permian Basin in Odessa who has studied the safety issue in stadiums. "But then you start making exceptions for people with kids, and for the elderly and for women with purses and people in expensive seats. Where does it end? You can have a policy or not have a policy. But once you start selectively enforcing it, that's going to be problematic."

After the bombings, the NHL's Boston Bruins added metal-detecting wands to their security regimen and checked cars parking in a garage underneath the arena. Security measures vary by arena in the NHL. The New York Islanders, for example, don't allow backpacks; the Detroit Red Wings ban oversized bags and search all bags that are allowed in.

Catsam said security can always be ratcheted up, but then comes the issue of how much convenience people are willing to give up for the sake of safety.

"They could start saying you can bring whatever kind of backpack you want but you have to go through an X-ray system like you do at the airport," he said. "It would take forever and we'd adjust, but I'm not sure what we'll discover or if we'll be making anything really safer."

Marciani, on the other hand, envisions a day when backpacks are as obsolete at a stadium as the bulky transistor radios that fans once brought along so they could listen to play-by-play as they watched the game.

"I think it's just one less aggravation we'd have to put up with," he said. "I'd just say, 'Why backpacks at a stadium?' I don't think we need them."

___

AP Sports Writers Pat Graham in Denver, Howard Fendrich in Washington, Stephen Wilson, Rob Harris, Steve Douglas and Chris Lehourites in London, Tales Azzoni in Sao Paolo, Brazil, Janie McCauley in San Francisco, Jon Krawczynski in Minneapolis, Graham Dunbar in Geneva, Jimmy Golen in Boston, Ben Walker and Ron Blum in New York, David Ginsburg in Baltimore and Bernie Wilson in San Diego and Associated Press reporter Peter Banda contributed to this report.

Source: http://news.yahoo.com/marathon-deaths-prompt-review-security-policy-192823940.html

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Hitting 'reset' in protein synthesis restores myelination: Suggests new treatment for misfolded protein diseases such as Alzheimer's

Apr. 26, 2013 ? A potential new treatment strategy for patients with Charcot-Marie-Tooth disease is on the horizon, thanks to research by neuroscientists now at the University at Buffalo's Hunter James Kelly Research Institute and their colleagues in Italy and England.

The institute is the research arm of the Hunter's Hope Foundation, established in 1997 by Jim Kelly, Buffalo Bills Hall of Fame quarterback, and his wife, Jill, after their infant son Hunter was diagnosed with Krabbe Leukodystrophy, an inherited fatal disorder of the nervous system. Hunter died in 2005 at the age of eight. The institute conducts research on myelin and its related diseases with the goal of developing new ways of understanding and treating conditions such as Krabbe disease and other leukodystrophies.

Charcot-Marie-Tooth or CMT disease, which affects the peripheral nerves, is among the most common of hereditary neurological disorders; it is a disease of myelin and it results from misfolded proteins in cells that produce myelin.

The new findings sere published online earlier this month in The Journal of Experimental Medicine.

They may have relevance for other diseases that result from misfolded proteins, including Alzheimer's disease, Parkinson's, multiple sclerosis, Type 1 diabetes, cancer and mad cow disease.

The paper shows that missteps in translational homeostasis, the process of regulating new protein production so that cells maintain a precise balance between lipids and proteins, may be how some genetic mutations in CMT cause neuropathy.

CMT neuropathies are common, hereditary and progressive; in severe cases, patients end up in wheelchairs. These diseases significantly affect quality of life but not longevity, taking a major toll on patients, families and society, the researchers note.

"It's possible that our finding could lead to the development of an effective treatment not just for CMT neuropathies but also for other diseases related to misfolded proteins," says Lawrence Wrabetz, MD, director of the institute and professor of neurology and biochemistry in UB's School of Medicine and Biomedical Sciences and senior author on the paper. Maurizio D'Antonio, of the Division of Genetics and Cell Biology of the San Raffaele Scientific Institute in Milan is first author; Wrabetz did most of this research while he was at San Raffaele, prior to coming to UB.

The research finding centers around the synthesis of misfolded proteins in Schwann cells, which make myelin in nerves. Myelin is the crucial fatty material that wraps the axons of neurons and allows them to signal effectively. Many CMT neuropathies are associated with mutations in a gene known as P0, which glues the wraps of myelin together. Wrabetz has previously shown in experiments with transgenic mice that those mutations cause the myelin to break down, which in turn, causes degeneration of peripheral nerves and wasting of muscles.

When cells recognize that the misfolded proteins are being synthesized, cells respond by severely reducing protein production in an effort to correct the problem, Wrabetz explains. The cells commence protein synthesis again when a protein called Gadd34 gets involved.

"After cells have reacted to, and corrected, misfolding of proteins, the job of Gadd34 is to turn protein synthesis back on," says Wrabetz. "What we have shown is that once Gadd34 is turned back on, it activates synthesis of proteins at a level that's too high -- that's what causes more problems in myelination.

"We have provided proof of principle that Gadd34 causes a problem with translational homeostasis and that's what causes some neuropathies," says Wrabetz. "We've shown that if we just reduce Gadd34, we actually get better myelination. So, leaving protein synthesis turned partially off is better than turning it back on, completely."

In both cultures and a transgenic mouse model of CMT neuropathies, the researchers improved myelin by reducing Gadd34 with salubrinal, a small molecule research drug. While salubrinal is not appropriate for human use, Wrabetz and colleagues at UB and elsewhere are working to develop derivatives that are appropriate.

"If we can demonstrate that a new version of this molecule is safe and effective, then it could be part of a new therapeutic strategy for CMT and possibly other misfolded protein diseases as well," says Wrabetz.

And while CMT is the focus of this particular research, the work is helping scientists at the Hunter James Kelly Research Institute enrich their understanding of myelin disorders in general.

"What we learn in one disease, such as CMT, may inform how we think about toxins for others, such as Krabbe's," Wrabetz says. "We'd like to build a foundation and answer basic questions about where and when toxicity in diseases begin."

The misfolded protein diseases are an interesting and challenging group of diseases to study, he continues. "CMT, for example, is caused by mutations in more than 40 different genes," he says. "When there are so many different genes involved and so many different mechanisms, you have to find a unifying mechanism: this problem of Gadd34 turning protein synthesis on at too high a level could be one unifying mechanism. The hope is that this proof of principle applies to more than just CMT and may lead to improved treatments for Alzheimer's, Parkinson's, Type 1 diabetes and the other diseases caused by misfolded proteins."

Co-authors with D'Antonio and Wrabetz are M. Laura Feltri, MD, professor of neurology and biochemistry at UB and a researcher with UB's Hunter James Kelly Research Institute at the NYS Center of Excellence in Bioinformatics and Life Sciences; Nicolo Musner, Cristina Scapin Daniela Ungaro and Ubaldo Del Carro from the San Raffaele Scientific Institute and David Ron of Cambridge and the National Institute for Health Research Cambridge Biomedical Research Centre.

Funding was provided by the National Institutes of Health, the European Community and an award to D'Antonio from the Italian Ministry of Health.

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The above story is reprinted from materials provided by University at Buffalo. The original article was written by Ellen Goldbaum.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. M. D'Antonio, N. Musner, C. Scapin, D. Ungaro, U. Del Carro, D. Ron, M. L. Feltri, L. Wrabetz. Resetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B mice. Journal of Experimental Medicine, 2013; 210 (4): 821 DOI: 10.1084/jem.20122005

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/_o1zELs2WuM/130426135037.htm

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Markets subdued ahead of US growth figures

LONDON (AP) ? The mood in financial markets was subdued Friday after a surprisingly big fall in Japanese prices and ahead of the first estimate of first-quarter economic growth in the U.S.

At the end of what's been a largely positive week, investors are gearing up for the growth figures. Despite a run of disappointing U.S. economic news, investors are relatively hopeful that the world's largest economy will post annualized growth of a little over 3 percent, well up on the previous quarter's 0.4 percent rate.

"Given the gains seen this week, an element of caution appears to be creeping into investor's mindset after a week of predominantly poor economic data," said Michael Hewson, senior market analyst at CMC Markets.

In Europe, the FTSE 100 index of leading British shares was down 0.7 percent to 6,400 while Germany's DAX fell the same rate to 7,784. The CAC-40 in France was 1.2 percent lower at 3,794.

Wall Street was poised for a lower opening with both Dow futures and the broader S&P 500 futures down 0.2 percent. How they will actually though will likely hinge on those GDP figures which are due for release an hour before the bell.

The dollar's fortunes over the day will likely hinge on the GDP figures too. Ahead of the release, the euro was up 0.1 percent at $1.3013.

Friday's session has also been dented by the news that prices in Japan are falling at their fastest rate in two years ? deflation is considered a bad thing as it can weigh on economic activity by giving consumers the incentive to hold off make purchases and by keeping a lid on wages. It also raises the relative value of a country's debt and for a country like Japan that's another problem.

The news that consumer prices in Japan fell by 0.9 percent in the year to March highlighted the scale of the challenge facing the Bank of Japan, which has been tasked to get inflation of 2 percent. In its attempt to do so, it announced a massive monetary stimulus package this month. It did not announce any new measures after its latest meeting Friday.

The prospect of more money in Japan has hit the yen hard to the likely benefit of the country's powerhouse exporters. And that's one reason why Tokyo's Nikkei 225 stock index has performed so strongly over the past few weeks.

However, the fall in prices weighed on Japanese stocks and gave the Asian session a soft tone. The Nikkei, which in the morning hit its highest intraday level in five years at 13,983.87, fell 0.3 percent to close at 13,884.13. The yen, however, clawed back some ground after the BoJ announcement of unchanged policies. The dollar was 0.8 percent lower at 98.59 yen.

"I think if there is anything to take from today's BoJ policy meeting it is the fact that the BoJ believes it has made all the announcements necessary in order to achieve its more aggressive inflation target," said Derek Halpenny, European head of global markets research at Bank of Tokyo-Mitsubishi UFJ.

Elsewhere in Asia, Hong Kong's Hang Seng rose 0.7 percent to 22,547.71 while South Korea's Kospi fell 0.4 percent at 1,944.56. Benchmarks in mainland China and India fell.

Benchmark oil for June delivery was down 62 cents to $93.02 per barrel in electronic trading on the New York Mercantile Exchange. The contract rose $2.21 to close at $93.64 on the Nymex on Thursday.

In currencies, the euro rose to $1.3027 from $1.3002 late Thursday in New York. The dollar fell to 98.72 yen from 99.31 yen.

Source: http://news.yahoo.com/markets-subdued-ahead-us-growth-figures-095800274--finance.html

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A way of life - Tampa Bay Newspapers

ST. PETE BEACH ? Shane Webb has always spent a lot of time on or near the water.

Whether it was teaching himself how to surf as a kid while on family vacations in Daytona Beach, riding a wave in Hawaii or paddleboarding down the Tennessee River in his hometown of Chattanooga, the desire to be involved in some type of water sport has been a part of his life.

So when the opportunity came a few years ago to open a paddleboard rental business with a partner in Tennessee, Webb decided it was time to end a 12-year career as a police officer and take the plunge, so to speak.

?You either get on or get off,? he said.

Webb decided to get on. Since then, he has expanded his business to include a shop and rentals on the beach behind the Post Card Inn.

His shop, Saltwater Kite and Paddle, at 6340 Gulf Blvd., specializes in the sale of paddleboards and kiteboards, but the bulk of time is spent next to the surf watching over his paddleboard rentals.

Webb, 39, and his fianc?e Grace Marcel, are entrepreneurs in one of the fastest growing recreation water sports in America.

Both offer kiteboarding lessons and rentals, but prefer to steer most people toward the safer sport of paddleboarding.

?It?s way easier and a much more forgiving sport,? said Webb, whose nickname is Waterboy. ?If you have the least bit of coordination you can do it.?

He said the sport dates back to the 1920s in Hawaii when former U.S. Olympic swimmer Duke Kahanamoku taught surfing lessons. Many of Kahanamoku?s students wanted keepsake photographs and because of the distance offshore, beach photographers couldn?t get good shots. Opportunistic photographers would paddle out on surfboards and carefully shoot their subjects without losing control of their cameras.

More recently, American surfer Laird Hamilton has taken up the sport, spurring a new generation of interest in the sport.

?Not everybody can surf,? said Webb. ?This is the closest a lot of people will come to surfing.?

Because of that, he said the sport has grown ?like wildfire? the last three or four years.

?Most surf shops have gone to them (paddleboards) because they?re so easy to use,? Webb said.

On a good day, Webb said he rents boards to about 25 people. Rates are $35 for an hour, $25 for a half-hour and $55 for three hours.

?We give a short tutorial,? he said. ?We tell them do this and don?t do that to make sure everybody is on the same page as far as safety.?

This compares with three to four hours of instruction before turning someone loose with the more expensive kiteboarding equipment.

For the most part, the tranquil water of the Gulf of

Mexico is perfect for paddleboarding.

?Typically, we have flat enough days and flatter makes it easier to learn,? Webb said. ?We don?t even open if it?s too rough.?

He?s rented boards to all ages, ranging from 6 to 73.

?If you?re in shape and have the slightest amount of coordination, you can do it,? he said.

Webb rents varying sizes of paddleboards but said his ?magic number? is 10-feet, 6 inches to 11 feet in length and 30 to 32 inches wide.

Good boards range in price from $1,000 to $2,000 and good paddles run about $250.

Webb also organizes a pair of paddleboarding events each year. The Tampa Bay Winter SUP Series is held from December to February and the Pacifico Paddle Challenge races are held in early November.

This year the third edition of the Paddle Challenge will be a two-day event on Nov. 9-10. It will include zigzag races, relays, kids competition, an 8-mile distance race and a 4-mile open race.

New this year will be the addition of kayaks, outrigger canoes and prone paddleboards.

Plans also call for a luau, complete with Polynesian dancers from Walt Disney World, live music and plenty of good food. The luau will be included in the entry fee for the race competitors but the general public can also take part too. Cost will be $10 for adults, $5 for children, Webb said.

?We want to get the community involved and to come out and watch the competition,? Webb said. ?We want to push the kids participation to get the community involved more and to understand the sport.?

For more information on the Paddle Challenge or paddleboarding in general, stop by Webb?s shop or give him a call at 423-463-1847.

Source: http://www.tbnweekly.com/pubs/beach_beacon/content_articles/042413_bhb-03.txt

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Putin: Boston bombing shows West's mistake

MOSCOW (AP) ? The Boston bombings should spur stronger security cooperation between Moscow and Washington, Russian President Vladimir Putin said Thursday, adding that they also show that the West was wrong in supporting militants in Chechnya.

Putin said that "this tragedy should push us closer in fending off common threats, including terrorism, which is one of the biggest and most dangerous of them."

The two brothers accused of the Boston bombings are ethnic Chechens who had lived in the U.S. for more than a decade.

Putin warned against trying to find the roots for the Boston tragedy in the suffering endured by the Chechen people, particularly in mass deportations of Chechens to Siberia and Central Asia on Soviet dictator Josef Stalin's orders. "The cause isn't in their ethnicity or religion, it's in their extremist sentiments," he said.

Speaking in an annual call-in show on state television, Putin criticized the West for refusing to declare Chechen militants terrorists and for offering them political and financial assistance in the past.

"I always felt indignation when our Western partners and Western media were referring to terrorists who conducted brutal and bloody crimes on the territory of Russia as rebels," Putin said.

The U.S. has urged the Kremlin to seek a political settlement in Chechnya and criticized rights abuses by Russian troops during the two separatist wars since 1994, which spawned an Islamic insurgency that has engulfed the entire region.

It also provided humanitarian aid to the region during the high points of fighting there in the 1990s and the early 2000s.

Russian officials have repeatedly claimed that rebels in Chechnya have close links with al-Qaida. They say dozens of fighters from Arab countries trickled into the region during the fighting there, while some Chechen militants have gone to fight in Afghanistan.

Putin said the West should have cooperated more actively with Russia in combatting terror.

"We always have said that we shouldn't limit ourselves to declarations about terrorism being a common threat and engage in closer cooperation," he said. "Now these two criminals have proven the correctness of our thesis."

Source: http://news.yahoo.com/putin-boston-bombing-shows-wests-mistake-101701441.html

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Forced exercise may still protect against anxiety and stress

Apr. 25, 2013 ? Being forced to exercise may still help reduce anxiety and depression just as exercising voluntarily does, according to a new study by researchers at the University of Colorado Boulder.

Past studies have shown that people who exercise are more protected against stress-related disorders. And scientists know that the perception of control can benefit a person's mental health. But it has been an open question whether a person who feels forced to exercise, eliminating the perception of control, would still reap the anxiety-fighting benefits of the exercise.

People who may feel forced to exercise could include high school, college and professional athletes, members of the military or those who have been prescribed an exercise regimen by their doctors, said Benjamin Greenwood, an assistant research professor in CU-Boulder's Department of Integrative Physiology.

"If exercise is forced, will it still produce mental health benefits?" Greenwood asked. "It's obvious that forced exercise will still produce peripheral physiological benefits. But will it produce benefits to anxiety and depression?"

To seek an answer to the question Greenwood and his colleagues, including Monika Fleshner, a professor in the same department, designed a lab experiment using rats. During a six-week period, some rats remained sedentary, while others exercised by running on a wheel.

The rats that exercised were divided into two groups that ran a roughly equal amount of time. One group ran whenever it chose to, while the other group ran on mechanized wheels that rotated according to a predetermined schedule. For the study, the motorized wheels turned on at speeds and for periods of time that mimicked the average pattern of exercise chosen by the rats that voluntarily exercised.

After six weeks, the rats were exposed to a laboratory stressor before testing their anxiety levels the following day. The anxiety was quantified by measuring how long the rats froze, a phenomenon similar to a deer in the headlights, when they were put in an environment they had been conditioned to fear. The longer the freezing time, the greater the residual anxiety from being stressed the previous day. For comparison, some rats were also tested for anxiety without being stressed the day before.

"Regardless of whether the rats chose to run or were forced to run they were protected against stress and anxiety," said Greenwood, lead author of the study appearing in the European Journal of Neuroscience in February. The sedentary rats froze for longer periods of time than any of the active rats.

"The implications are that humans who perceive exercise as being forced -- perhaps including those who feel like they have to exercise for health reasons -- are maybe still going to get the benefits in terms of reducing anxiety and depression," he said.

Other CU-Boulder authors include Katie Spence, Danielle Crevling, Peter Clark and Wendy Craig. All the authors are members of Monika Fleshner's Stress Physiology Laboratory in the Department of Integrative Physiology.

The research was funded by the National Institutes of Mental Health and the Defense Advanced Research Projects Agency.

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The above story is reprinted from materials provided by University of Colorado at Boulder, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Benjamin N. Greenwood, Katie G. Spence, Danielle M. Crevling, Peter J. Clark, Wendy C. Craig, Monika Fleshner. Exercise-induced stress resistance is independent of exercise controllability and the medial prefrontal cortex. European Journal of Neuroscience, 2013; 37 (3): 469 DOI: 10.1111/ejn.12044

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/t1WiQj6G-qk/130425160212.htm

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Quora Snags John Hegeman From Facebook To Lead Its Engineering Efforts

Screen Shot 2013-04-25 at 10.47.26 AMWe've just gotten word that Facebook's Director of Engineering for Ads, John Hegeman, will be moving to Quora to lead the Quora engineering team. While I haven't received direct confirmation from either Quora or Hegeman on the hire, Hegeman has apparently confirmed the move on his (private) Facebook Timeline according to a tipster, writing:

Source: http://feedproxy.google.com/~r/Techcrunch/~3/M7uetRaiFf4/

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Four children die in S. Carolina mobile home fire

HARTSVILLE, S.C. (AP) ? Authorities say four children have been killed in a mobile home fire in the South Carolina city of Hartsville.

Darlington County Coroner Todd Hardee said twin 1-year-old girls and their brothers aged 3 and 4 were found dead in the home after the fire was put out Wednesday afternoon.

Hardee said autopsies have been scheduled for Thursday to determine the cause of death and their identities.

Sheriff Wayne Byrd said the mother was in the yard when firefighters arrived. He didn't elaborate.

The fire is under investigation by both the sheriff 's department and the State Law Enforcement Division. No charges have been filed and authorities were preparing to talk with the mother.

Hartsville is a city of some 8,000 people about 60 miles east of the state capital, Columbia.

Source: http://news.yahoo.com/official-4-children-killed-sc-mobile-home-fire-195420381.html

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Thursday, April 25, 2013

Droid DNA clone HTC Deluxe coming to Cellcom

HTC Deluxe

The HTC Deluxe shows up again, this time in Wisconsin

Cellcom, the regional carrier from Wisconsin, has unveiled their next marquee device -- the HTC Deluxe. It's basically the HTC Droid DNA repackaged for the small network, which means it's a pretty damn good piece of equipment. If you need a refresher, that means it has a quad-core Snapdragon Pro CPU, a 5-inch 1080p display, 2GB of RAM, and an LTE radio to keep the data flowing.

No word on when it will arrive, just that it's coming "soon" for $199 with a new contract or $570 if you buy it outright. If you're a Cellcom subscriber, this is definitely worth a second look. See the source link for more details.

Source: Cellcom. Thanks, Aaron!

    


Source: http://feedproxy.google.com/~r/androidcentral/~3/fK2q38KudJU/story01.htm

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Ice tubes in polar seas -- 'brinicles' or 'sea stalactites' -- provide clues to origin of life

Apr. 24, 2013 ? Life on Earth may have originated not in warm tropical seas, but with weird tubes of ice -- sometimes called "sea stalactites" -- that grow downward into cold seawater near Earth's poles, scientists are reporting. Their article on these "brinicles" appears in ACS' journal Langmuir.

Bruno Escribano and colleagues explain that scientists know surprisingly little about brinicles, which are hollow tubes of ice that can grow to several yards in length around streamers of cold seawater under pack ice. That's because brinicles are difficult to study. The scientists set out to gather more information on the topic with an analysis of the growth process of brinicles.

They are shown to be analogous to a "chemical garden," a standby demonstration in chemistry classes and children's chemistry sets, in which tubes grow upward from metal salts dropped into silicate solution. But brinicles grow downward from the bottom of the ice pack.

The analysis concluded that brinicles provide an environment that could well have fostered the emergence of life on Earth billions of years ago, and could have done so on other planets. "Beyond Earth, the brinicle formation mechanism may be important in the context of planets and moons with ice-covered oceans," the report states, citing in particular two moons of Jupiter named Ganymede and Callisto.

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The above story is reprinted from materials provided by American Chemical Society.

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Journal Reference:

  1. Julyan Cartwright, Bruno Escribano, Diego L. Gonz?lez, Claro Ignacio Sainz-Diaz, idan tuval. Brinicles as a case of inverse chemical gardens. Langmuir, 2013; : 130403173604005 DOI: 10.1021/la4009703

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/strange_science/~3/DaSQJwKHSz4/130424112316.htm

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Battling with bugs to prevent antibiotic resistance

Apr. 23, 2013 ? New scientific research published today in the journal PLoS Biology shows that bacteria can evolve resistance more quickly when stronger antibiotics are used.

Researchers from the University of Exeter and Kiel University in Germany treated E. coli with different combinations of antibiotics in laboratory experiments.

Unexpectedly they found that the rate of evolution of antibiotic resistance speeds up when potent treatments are given because resistant bacterial cells flourish most during the most aggressive therapies.

This happens because too potent a treatment eliminates the non-resistant cells, creating a lack of competition that allows resistant bacteria to multiply quickly. Those cells go on to create copies of resistance genes that help them rapidly reduce the effectiveness of the drugs. In tests this effect could even cause E.coli to grow fastest in the most aggressive antibiotic treatments.

In addition to evolution experiments, the results of this Engineering and Physical Sciences Research Council (EPSRC) and Medical Research Council (MRC) funded research were confirmed using mathematical models and whole-genome sequencing of resistant and non-resistant E. coli.

Professor Robert Beardmore, EPSRC Research Fellow from the University of Exeter said: "We were surprised by how quickly the bacteria evolved resistance. We nearly stopped the experiments because we didn't think some of the treatments should be losing potency that fast, sometimes within a day. But we now know that the bacteria remaining after the initial treatment have duplicated specific areas of their genome containing large numbers of resistance genes. These gene copies appear more quickly when the antibiotics are combined, resulting in the rapid evolution of very resistant bacteria.

"Designing new treatments to prevent antibiotic resistance is not easy, as this research shows, and governments may need to increase their funding for antibiotics research if scientists are to be able to keep pace with the rapid evolution of bacterial pathogens that cause disease."

Dr Rafael Pena-Miller from Biosciences at the University of Exeter said: "The evidence that combining antibiotics to make a more potent therapy can lead to the creation of more copies of the genes the bacteria needs to be resistant is of real concern."

Professor Hinrich Schulenberg from Kiel University in Germany said: "The interesting thing is that the bacteria don't just make copies of the genes they need. Just in case, they copy other genes as well, increasing resistance to antibiotics the cells weren't even treated with."

About 440 000 new cases of drug-resistant tuberculosis emerge annually, causing around 150 000 deaths. Statistics like this recently lead the Department of Health to state that antibiotic resistance poses one of the greatest threats to human health.

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The above story is reprinted from materials provided by University of Exeter, via EurekAlert!, a service of AAAS.

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Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/zprA_T5Qf9w/130423172704.htm

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