FDA can't find cause of pet poison, seeks help

This Sept. 2013 image provided by Patricia Cassidy shows her dog Doodles, while he was sick right before his Sept. 9, death, in Chattanooga, Tenn. Doodles is believed to be one of 580 dogs in the U.S. that have died in the past six years from eating pet jerky from China. Baffled by the cause and seeing another surge in illnesses, the Food and Drug Administration reached out to owners and veterinarians Tuesday to help it find the poison behind the sickening of at least 3,600 dogs and 10 cats since 2007. (AP Photo/Patricia Cassidy)

This Sept. 2013 image provided by Patricia Cassidy shows her dog Doodles, while he was sick right before his Sept. 9, death, in Chattanooga, Tenn. Doodles is believed to be one of 580 dogs in the U.S. that have died in the past six years from eating pet jerky from China. Baffled by the cause and seeing another surge in illnesses, the Food and Drug Administration reached out to owners and veterinarians Tuesday to help it find the poison behind the sickening of at least 3,600 dogs and 10 cats since 2007. (AP Photo/Patricia Cassidy)

This July 2013 image provided by Patricia Cassidy shows her dog Doodles, in Chattanooga, Tenn. Doodles is believed to be one of 580 dogs in the U.S. that have died in the past six years from eating pet jerky from China. Baffled by the cause and seeing another surge in illnesses, the Food and Drug Administration reached out to owners and veterinarians Tuesday to help it find the poison behind the sickening of at least 3,600 dogs and 10 cats since 2007. (AP Photo/Patricia Cassidy)

This July 2013 image provided by Patricia Cassidy shows Cassidy with her dog, Doodles, at the veterinarian in Chattanooga, Tenn., after doodles had been diagnosed with kidney failure. Doodles is believed to be one of 580 dogs in the U.S. that have died in the past six years from eating pet jerky from China. Baffled by the cause and seeing another surge in illnesses, the Food and Drug Administration reached out to owners and veterinarians Tuesday to help it find the poison behind the sickening of at least 3,600 dogs and 10 cats since 2007. (AP Photo/Courtesy Patricia Cassidy)

This Sept. 2013 image provided by Patricia Cassidy shows an impression of her dog Doodles' paw print. Doodles is believed to be one of 580 dogs in the U.S. that have died in the past six years from eating pet jerky from China. Baffled by the cause and seeing another surge in illnesses, the Food and Drug Administration reached out to owners and veterinarians Tuesday to help it find the poison behind the sickening of at least 3,600 dogs and 10 cats since 2007. (AP Photo/Patricia Cassidy)

LOS ANGELES (AP) — All that's left of Doodles are his ashes, a clay impression of his paw and a whole lot of questions owner Patricia Cassidy has about his mysterious death.

Doodles is believed to be one of 580 dogs in the U.S. that have died in the past six years from eating pet jerky from China. Baffled by the cause and seeing another surge in illnesses, the Food and Drug Administration reached out to owners and veterinarians Tuesday to help it find the poison behind the sickening of at least 3,600 dogs and 10 cats since 2007.

Within hours of eating the suspect jerky, pets lost their appetite, became lethargic, vomited and had diarrhea and other symptoms. The strips made of chicken, duck, sweet potatoes or dried fruit were sold under a variety of brand names.

There was a decrease in 2007 after some products were voluntarily removed from the market, but the FDA said it didn't want to conduct a recall without a definitive cause. Those products included Milo's Kitchen Chicken Jerky Treats and Chicken Grillers, made by Del Monte, and Waggin' Train and Canyon Creek Ranch dog treats, made by Nestle Purina.

But in the years since, the FDA has gotten complaints from pet owners and veterinarians who have seen repeated cases of kidney failure, gastrointestinal bleeding, and a rare kidney disorder, the FDA said.

The FDA's Center for Veterinary Medicine has run more than 1,200 tests, visited pet treat manufacturing plants in China and worked with researchers, state labs and foreign governments but hasn't determined the exact cause of the illness.

Testing is complicated because the poison may have come from the manufacturing plant, shipping, transportation or anywhere along the way. Scientists have to know what they're looking for to test for it.

"I grew up watching 'Quincy' and 'CSI' and they have given us this look at forensics — you put samples in and answers come out the other end," said Dr. Tina Wismer, medical director of the Animal Poison Control Center of the American Society for the Prevention of Cruelty to Animals. It doesn't work that way."

That's little consolation to Cassidy in Chattanooga, Tenn. Doodles died Sept. 9 at the age of 6. In just three months, he turned from a vibrant 16-pound shih tzu into a frail, 6-pounder who couldn't eat or drink and had so little left in him he could only vomit yellow bile.

"He was such a loving little guy and so cute. Every day my daughter will say, 'Mom, I don't know when the holes in our hearts will be repaired.'"

Cassidy promised Doodles she would wage war as long as it took to get the products off store shelves or, at the very least, labeled so people know it might be deadly.

The jerky mystery is the worst case of tainted pet food from China since 2007 when there was a nationwide recall of food made by Menu Foods and 1,950 cats and 2,200 dogs died. Kidney failure caused all of those pet deaths and the poison was found to be tainted melamine from plastic packaging in the wheat gluten. About 150 brands of dog and cat food were recalled and included some of the biggest names in pet food.

A federal grand jury indicted two Chinese nationals and the businesses they operate, as well as the U.S, company ChemNutra Inc. and its CEO for their roles in importing the poisonous products. A class-action lawsuit awarded more than $12.4 million in compensation to pet owners whose pets died from the poisoned food.

Veterinarians can only tell pet owners they don't know what's causing their animals to get sick and that's hard to do, said Dr. Karl Jandrey, an emergency and critical care vet at the Veterinary Medical Teaching Hospital at the University of California, Davis. They have treated several dogs for what they believe was poisoning from the treats, but no patient has died, he said.

Dexter, a 3-year-old, 19-pound miniature schnauzer also survived, but it cost owner Rich Phillips of North Richland Hills, Texas, about $1,200, he said.

In April, Dexter started throwing up and couldn't stop. He spent the night at an emergency clinic and the next day at the vet's. Test after test was inconclusive. The dog was given an IV and anti-nausea medicine and sent home. That's when Phillips saw the package of chicken jerky treats and knew that was the cause. "We were lucky we caught him quick," Phillips said. Dexter had only had about two of the treats and has been fine ever since that night.

No one knows how many treats a pet has to eat before it starts getting sick, said Dr Amy Bowman, regional medical director for Banfield Pet Hospital in Reston, Va.

"Some say it's a single serving, some say the whole bag," she said. Her advice is to avoid jerky treats if the label says it comes from China. There are all kinds of healthy treat substitutes, including apples, uncooked green beans and carrots, she added.

A lot of pet owners transfer food and treats into other containers at home to keep pets and pests out, but Wismer suggested keeping labels with lot numbers and manufacturers.

Imported pet food is inspected when it arrives in the United States but only randomly and to check for things like mold, Wismer said.

Dr. Barry Kellogg, senior adviser to the Humane Society Veterinary Medical Association, called for increased testing and stricter guidelines on labeling of imports. If only part of a product is from China and it is put together here, labels don't have to say made in China, he said.

___

Writer Mary Clare Jalonick reported on this story from Washington.

___

Online:

Food and Drug Administration statement http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm371413.htm

Associated PressSource: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-10-24-Pets-Snack%20Warning/id-c448b97ba189464aa2c5ee437da3f73c
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Plants vs. Zombies 2 shambles its way to Android devices worldwide

After brief test runs in Australia and New Zealand, EA and PopCap have released Plants vs. Zombies 2 for Android users worldwide. The new version is virtually identical to the iOS game released this summer, letting players fend off the undead hordes on both phones and tablets. The biggest change ...

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Caterpillar leads Dow lower as a stock rally fades

NEW YORK (AP) — A four-day streak of record closes is ending for the Standard & Poor's 500 index after Caterpillar reported weak earnings and falling oil prices hurt energy stocks.

Caterpillar, which makes mining and construction equipment, led the Dow Jones industrial average lower after reporting a plunge in third-quarter earnings. That discouraged investors and stalled a two-week surge in the stock market.

Energy stocks dropped as the price of oil fell to its lowest in almost four months.

The S&P 500 fell eight points, or 0.5 percent, to 1,746. The Dow gave up 54 points to close at 15,413 and the Nasdaq composite fell 22 points, or 0.6 percent, to 3,907.

More stocks fell than rose on the New York Stock Exchange. Volume was heavier than usual at 3.7 billion shares.

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Source: http://news.yahoo.com/caterpillar-leads-dow-lower-stock-rally-fades-160021235--finance.html
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A protein safeguards against cataracts

PUBLIC RELEASE DATE:

23-Oct-2013

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Contact: Dr. Andreas Battenberg
andreas.battenberg@tum.de
49-892-891-0510
Technische Universitaet Muenchen

Activation mechanism of a protective protein in the ocular lens resolved

This news release is available in German.

The lens of the human eye is made up of a highly concentrated protein solution that imparts the eye its high refractive power. Yet, despite this high protein content the ocular lens must remain clear and transparent. To this end ocular lens cells have developed a remarkable strategy: They have thrown overboard the complex machinery present in all other cells of the human body for building up and breaking down proteins. Instead, lens proteins are created only once in a lifetime during embryonic development. They are as old as the organism itself. To make them last a lifetime, the proteins are kept permanently in a dissolved state. If they clump together, the lens clouds over and the patient gets cataracts.

Alternative to surgery

To date, this condition could only be treated surgically by replacing the clouded lens with an artificial one. However, if the precise mechanism by which lens proteins are kept in a dissolved state were understood, it would open up new avenues for treatment. So, how does the cell manage to keep the proteins soluble for so long? The magic lies in two proteins, αA-crystallin and its relative, αB-crystallin. They are the best-known representatives of the class of so-called small heat shock proteins. They play an important role in all human cells, since they prevent other proteins from turning into useless clumps when subjected to strong heat or cell stress.

What exactly these protective proteins look like and how they act remained shrouded in mystery for a long time, in spite of intensive research. "The great challenge in the analysis of these two crystallin types lies in their inordinate variety," explains Johannes Buchner, professor for biotechnology at the Technische Universitaet Muenchen. "These proteins exist as a mixture of very different forms, each comprising a variable number of subunits. This makes it very difficult to distinguish the individual structures from one another."

Molecular switch

In 2009, in very close collaboration with Sevil Weinkauf, professor for electron microscopy at the Technische Universitaet Muenchen, the first part of the αB-crystallin puzzle fell into place. The team successfully deciphered the molecular structure of the most important form of this versatile protein a molecule comprising 24 subunits. Under normal conditions, i.e. when the cell is not exposed to stress, this complex is the most common variant. However, it is merely an idle form that contributes little to the prevention of clumping in other proteins. It was clear that there must be another molecular switch that triggers the protective protein.

It is this trigger mechanism that the team headed by Buchner and Weinkauf uncovered now. When a cell is exposed to stress, for instance when subjected to heat, phosphate groups are attached to a specific region of the protein. The negative charges of these phosphates break the links between the subunits and the large complexes consequently disintegrate into numerous smaller ones of only six or twelve subunits each. As a result of this breakup, the regions at the ends of the complexes become more flexible allowing the molecules to dock up with different partners, thereby preventing them from clumping the protective protein is now active.

Interdisciplinary cooperation

The success of the scientists can be traced back above all to the interdisciplinary combination of biochemical and electron-microscopic methodologies. Aligning the information from the two-dimensional protein disintegration images with the manifold three-dimensional structures of αB-crystallin proved particularly difficult. "Imagine you only have a few pictures of a coffee cup's shadow cast and want to infer the shape of the cup from that," Weinkauf explains to illustrate the problem. "Now, if you think that sounds difficult, try to imagine you have not just a single cup, but a cupboard full of china that you want to deduce from the shadow casts. It is precisely this daunting challenge that we met for αB-crystallin."

The newly acquired insights into the αB-crystallin mode of action form a solid footing for new therapeutic approaches. For instance, medication to treat cataracts could be developed: it would trigger the αB-crystallin activation mechanism to clear up clouded ocular lenses. But αB-crystallin also plays a role in other tissue cells. In cancer cells, for example, it is overly active and interferes with the so-called programmed cell death. In this case new medication would aim at inhibiting the protein.

###

The work has been funded by German Research Foundation (Cluster of Excellence Center for Integrated Protein Science Munich (CIPSM) and SFB 1035).

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PUBLIC RELEASE DATE:

23-Oct-2013

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Contact: Dr. Andreas Battenberg
andreas.battenberg@tum.de
49-892-891-0510
Technische Universitaet Muenchen

Activation mechanism of a protective protein in the ocular lens resolved

This news release is available in German.

The lens of the human eye is made up of a highly concentrated protein solution that imparts the eye its high refractive power. Yet, despite this high protein content the ocular lens must remain clear and transparent. To this end ocular lens cells have developed a remarkable strategy: They have thrown overboard the complex machinery present in all other cells of the human body for building up and breaking down proteins. Instead, lens proteins are created only once in a lifetime during embryonic development. They are as old as the organism itself. To make them last a lifetime, the proteins are kept permanently in a dissolved state. If they clump together, the lens clouds over and the patient gets cataracts.

Alternative to surgery

To date, this condition could only be treated surgically by replacing the clouded lens with an artificial one. However, if the precise mechanism by which lens proteins are kept in a dissolved state were understood, it would open up new avenues for treatment. So, how does the cell manage to keep the proteins soluble for so long? The magic lies in two proteins, αA-crystallin and its relative, αB-crystallin. They are the best-known representatives of the class of so-called small heat shock proteins. They play an important role in all human cells, since they prevent other proteins from turning into useless clumps when subjected to strong heat or cell stress.

What exactly these protective proteins look like and how they act remained shrouded in mystery for a long time, in spite of intensive research. "The great challenge in the analysis of these two crystallin types lies in their inordinate variety," explains Johannes Buchner, professor for biotechnology at the Technische Universitaet Muenchen. "These proteins exist as a mixture of very different forms, each comprising a variable number of subunits. This makes it very difficult to distinguish the individual structures from one another."

Molecular switch

In 2009, in very close collaboration with Sevil Weinkauf, professor for electron microscopy at the Technische Universitaet Muenchen, the first part of the αB-crystallin puzzle fell into place. The team successfully deciphered the molecular structure of the most important form of this versatile protein a molecule comprising 24 subunits. Under normal conditions, i.e. when the cell is not exposed to stress, this complex is the most common variant. However, it is merely an idle form that contributes little to the prevention of clumping in other proteins. It was clear that there must be another molecular switch that triggers the protective protein.

It is this trigger mechanism that the team headed by Buchner and Weinkauf uncovered now. When a cell is exposed to stress, for instance when subjected to heat, phosphate groups are attached to a specific region of the protein. The negative charges of these phosphates break the links between the subunits and the large complexes consequently disintegrate into numerous smaller ones of only six or twelve subunits each. As a result of this breakup, the regions at the ends of the complexes become more flexible allowing the molecules to dock up with different partners, thereby preventing them from clumping the protective protein is now active.

Interdisciplinary cooperation

The success of the scientists can be traced back above all to the interdisciplinary combination of biochemical and electron-microscopic methodologies. Aligning the information from the two-dimensional protein disintegration images with the manifold three-dimensional structures of αB-crystallin proved particularly difficult. "Imagine you only have a few pictures of a coffee cup's shadow cast and want to infer the shape of the cup from that," Weinkauf explains to illustrate the problem. "Now, if you think that sounds difficult, try to imagine you have not just a single cup, but a cupboard full of china that you want to deduce from the shadow casts. It is precisely this daunting challenge that we met for αB-crystallin."

The newly acquired insights into the αB-crystallin mode of action form a solid footing for new therapeutic approaches. For instance, medication to treat cataracts could be developed: it would trigger the αB-crystallin activation mechanism to clear up clouded ocular lenses. But αB-crystallin also plays a role in other tissue cells. In cancer cells, for example, it is overly active and interferes with the so-called programmed cell death. In this case new medication would aim at inhibiting the protein.

###

The work has been funded by German Research Foundation (Cluster of Excellence Center for Integrated Protein Science Munich (CIPSM) and SFB 1035).

---

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| E-mail


Share

]

 

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-10/tum-aps102313.php
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Canada sex offender pleads not guilty to US charge

SEATTLE (AP) — A violent sex offender who fled Canada pleaded not guilty Wednesday to a harassment charge in Seattle as police explored the possibility of additional charges related to a sexual assault.

Wearing a red jail uniform with his hands shackled in front of him, Michael Sean Stanley made a first appearance by video feed from the local detention center. Seattle Municipal Court Judge Karen Donohue set his bail at $100,000.

Nic Gross, the public defender appearing for Stanley, sought his release and suggested that Stanley could be required to check in daily if the court wanted those conditions. Gross said that Stanley has an uncle and a cousin in the area who could get him work as a laborer, but Donohue questioned those family links and said the circumstances of his flight raised concerns about whether he would show up for future court hearings.

"The court does have concerns with the lack of ties Mr. Stanley has to Seattle," Donohue said.

The harassment case came from an incident Tuesday morning in which police say Stanley threatened someone who asked him to be quiet. Authorities are still working to re-book Stanley on more serious charges, saying he is being investigated for assaulting a 16-year-old boy.

In the assault case, authorities said Stanley met a boy at a west Seattle grocery store, struck up a conversation and walked with him to an alley where he plied the teen with alcohol and attacked him. The boy pulled a knife and was able to escape, police said.

Stanley had registered as a sex offender with the King County sheriff's office and listed his address as an intersection just a block away from Seattle's Pike Place Market, a scenic destination for both tourists and locals. It's also near a preschool, even though he had been ordered to stay away from children in Canada.

Ilene Stark, executive director at Pike Market Child Care and Preschool, said the community felt threatened by Stanley's arrival in the area. The preschool reviewed its lockdown plan, kept in constant contact with security in the area, and provided images and descriptions of Stanley to teachers and parents.

"It's been intense," Stark said. "It felt like there was a threat in our community and that we needed to be much more vigilant — more than in everyday life. It was disconcerting."

Stark said she was saddened that something horrible apparently had to happen before Stanley was collected by U.S. law enforcement. At the same time, she said her sadness was coupled with relief knowing that there is more legal control over Stanley's whereabouts.

Detectives believe the attack on the teen happened before police received several calls reporting noise in an alley and Stanley threatening someone who asked him to be quiet. When police arrived, Stanley became combative and said he had a knife. He appeared intoxicated, according to authorities. He was arrested and jailed for investigation of harassment.

Stanley most recently served a 32-month prison term after what parole documents describe as a case in which he lured two mentally challenged boys into an apartment, lit a crack pipe and blew smoke in their faces and then sexually assaulted them. Parole documents also describe another case in which Stanley broke into an elderly woman's apartment while she was sleeping and sexually assaulted her.

He was being monitored by police under a peace bond, which Canadian authorities can get to impose conditions on individuals in the community. Stanley's peace bond has 20 conditions, including one ordering him to stay away from children.

Police in Canada issued a public alert earlier this month after Stanley cut off his electronic-monitoring bracelet. Officials described him as an untreated, violent offender who posed a significant risk.

An American citizen, Stanley crossed the border and was located in the Seattle area last week. Canadian officials decided not to seek extradition.

Before Tuesday, there was no reason to arrest Stanley since Canada hadn't pursued an extraditable warrant and he wasn't wanted for any crimes in the United States, authorities said.

Edmonton, Alberta, police spokesman Chad Orydzuk told The Associated Press that Stanley's arrest in Seattle was "unfortunate but we can't provide comment. It's not our file."

"If he continues to break the law down south you can imagine how difficult it would be for us to comment if he broke the law in different jurisdictions in the States. For us to comment on that, we couldn't keep up with that, if this was to continue," he said.

Orydzuk said when Stanley breached the monitoring conditions in Edmonton, officials searched for him and notified the public and other agencies. Unconfirmed sightings of Stanley led schools in several west-central Saskatchewan communities to lock their doors and keep children inside.

___

Follow Mike Baker at https://twitter.com/MikeBakerAP.

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Source: http://news.yahoo.com/canada-sex-offender-pleads-not-guilty-us-charge-180756104.html
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Pat Miletich on MMA's refusal to throw in the towel, and why the loss of Strikeforce was so significant

Midway through UFC 166's heavyweight title fight, as a concussed Junior dos Santos ate heavy punch after heavy punch, unable or unwilling to mount any semblance of defense, Pat Miletich reached the same conclusion as UFC President Dana White -- the fight needed to be stopped.

Regardless referee Herb Dean, cageside physicians, and most questionable of all, dos Santos' corner, all allowed the Brazilian's beating to continue well into the fifth round, leading Miletich to join the chorus wondering why MMA corners are so hesitant to throw in the towel while the practice is widely accepted in boxing.

"God, you know, there's a lot of pride involved," Miletich said on Monday's edition of The MMA Hour.

"A lot of the guys that are cornering these guys, many times are training partners, pretty strong, virile young guys who don't see themselves as vulnerable probably, to be honest with you."

Miletich went on to cite an example of the problem in action at XFC 26, which aired live on AXS TV last weekend with Miletich in the broadcast booth.

"I witnessed a fight Friday night, Roger Carroll getting beat up by Scott Holtzman," Miletich explained. "It was a hell of fight, but Roger Carroll took a -- I can't even count how many elbows he took. His face was swollen shut and there was no use of the fight going on.

"I'd seen enough and I said that on TV. The boys agreed with me, but it wasn't getting stopped. I think it's just a matter of people not -- they care so much about the guy that they want to see him win. I don't know, they're blind at points. Junior dos Santos took a serious ass whopping, and I tend to agree with some people that, yes, that should've been stopped."

The primary concern in situations like dos Santos' is not the immediate danger -- although that definitely plays a part -- but rather, the potential for tremendous amounts of unnecessary damage to negativity impact fighters later in life.

"I think it's already there. I've seen it in guys that I've trained with in the earlier days," Miletich admitted.

"In both boxing and MMA, guys that aren't the same as they were when we were all young. So it's there."

Miletich has been around mixed martial arts long enough to hold a nuanced perspective on the sport's inner workings. The 47-year-old became the inaugural UFC welterweight champion in 1998, defended the belt four times, founded Miletich Fighting Systems -- a camp which at one time produced champions like an assembly line -- then, among other gigs, worked as a commentator to now-defunct Strikeforce.

When Strikeforce dissolved in early-2013, Miletich was struck particularly hard by the loss; not due to any lack of employment opportunities for himself, but rather, he saw it as a disastrous blow to fighters' ability to negotiate a proper income.

"It bothered me, because more than anything else, (the thing that helps) the growth of the sport and the development is athletes having the ability to truly have organizations bid on their talent and make more money for themselves," Miletich said.

"That's where the competition is important. It's healthy, and until that comes back, some sort of organization that could put something together like that, that was a loss for the sport and the athletes, and for the fans, quite frankly."

In the aftermath of Strikeforce's demise, Miletich believes the current MMA landscape leaves much to be desired. The way he sees it, the fighters at the very top of the ladder are getting compensated, but those below them are left to simply fend for themselves.

"There are a lot of places where guys can get their start," Miletich explained. "I think there's a lot of places where guys can gain experience and get their name known out there, to a certain extent, to make themselves marketable to then go on to the UFC.

"But until you have a place that can pay you as well or better than the existing king of the hill, then it's a pyramid and there's no options. There's no options for the athletes. The only reason I say this now is, having been an athlete, having been from the bottom of the ladder to the top, when there are no options, things tend to -- athletes have zero control. And the athletes definitely need control," Miletich said in closing.

"If I'm in the NFL, I have a lot of control because there are several teams, people are going to bid for my services. And that does not exist in this sport."

Source: http://www.mmafighting.com/2013/10/23/4867936/pat-miletich-on-mmas-refusal-to-throw-in-the-towel-and-why-the-loss
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Apple unveils Haswell-based MacBook Pros with Retina display, starting at $1,299 (update: non-Retina 15-inch is gone)

If you've been waiting for the MacBook Pro with Retina display to get a big processor upgrade, today's your lucky day. Apple has just refreshed its high-end portable line with Intel's Haswell chips, delivering Iris graphics and battery life improvements much like those from the recent MacBook Air ...

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/2NyPugh8Hu8/
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